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Childhood Growth Hormone Deficiency Noonan Syndrome Small for
Gestational Age Turner Syndrome

Indication and Usage

Norditropin® is used to treat children who are short (in stature) and who have Turner syndrome.

Turner Syndrome

You may have found out you have something called Turner syndrome and you may be feeling confused or even upset about this, but don't let it get you down! Other women and girls with Turner syndrome do a lot and have great lives. And the other good news is that there are now a lot of medicines to help with the conditions that come with Turner syndrome. Like helping girls with Turner syndrome grow taller.

Treatment With Norditropin®

Doctors usually prescribe a growth hormone like Norditropin® to help children grow taller. Norditropin® is exactly the same as the growth hormone your body makes to help it grow.

Norditropin® is usually taken once a day in the form of a shot. Thinking about a shot can be scary, but it may be easier than you think. Norditropin® comes in a special pen and has a small needle, and it's easy for you or your parents to learn to use.*

The other cool thing about the pen is that it comes with the medicine already inside. And, some Norditropin® pens don't have to stay in a fridge all the time. This means you can just put it in your backpack and pretty much take it almost anywhere you want to go. Most other growth hormone medicines can't do that.**

If you have more questions about Norditropin®, ask Mom or Dad, and if they don't have the answers, you can ask your doctor. Doctors like to answer kids' questions.

*Needles are sold separately and may require a prescription in some states.

**All Norditropin® products must be refrigerated prior to first use. Do not freeze. After initial use, FlexPro® 5 mg/1.5 mL and 10 mg/1.5 mL delivery pens can either be stored outside of the refrigerator (at up to 77°F) for use within 3 weeks, or in the refrigerator (between 36°F and 46°F) for use within 4 weeks. The FlexPro® 15 mg/1.5 mL and NordiFlex® 30 mg/3 mL delivery pens must always be refrigerated (between 36°F and 46°F)—both prior to and after the initial injection—for use within 4 weeks.

Learn More

To find out more about Turner syndrome, you might want to visit these other web sites:

The Turner Syndrome Society of the US www.turnersyndrome.org/

The National Institutes of Health http://turners.nichd.nih.gov/

The Magic Foundation® http://www.magicfoundation.org/www/docs/ 981.1070/turner_perspectives_jamie_harvey_erica_ eugster.html

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Important Safety Information Jump Link

Indications and Usage

Norditropin® (somatropin [rDNA origin] injection) is used to treat: children who have growth failure because of low or no growth hormone; children who are short (in stature) and who have Noonan syndrome or Turner syndrome; children who are short (in stature) because they were born small (small for gestational age-SGA) and have not caught-up in growth by age 2 to 4 years; and adults who do not make enough growth hormone.

Important Safety Information

Do not use Norditropin® if: you have a critical illness caused by certain types of heart or stomach surgery, trauma or breathing (respiratory) problems; you are a child with Prader-Willi syndrome who is severely obese or has breathing problems including sleep apnea; you have cancer or other tumors; your healthcare provider tells you that you have certain types of eye problems caused by diabetes; you are a child with closed bone growth plates (epiphyses) or you are allergic to any of the ingredients in the medicine.

Before you take Norditropin®, tell your healthcare provider if you: have diabetes; had cancer or any tumor; have any other medical condition; are pregnant or plan to become pregnant; are breast-feeding or plan to breast-feed.

Norditropin® can cause serious side effects, including: high risk of death in people who have critical illnesses because of heart or stomach surgery, trauma or serious breathing (respiratory) problems; high risk of death in children with Prader-Willi syndrome who are severely obese or have breathing problems including sleep apnea; return of tumor or cancerous growths; high blood sugar (hyperglycemia); increase in pressure in the skull (intracranial hypertension); swollen hands and feet due to fluid retention; decrease in thyroid hormone levels; hip and knee pain or a limp in children (slipped capital femoral epiphysis); worsening of pre-existing curvature of the spine (scoliosis); middle ear infection, hearing problems or ear problems in patients with Turner syndrome.

Patients with Noonan syndrome and Turner syndrome should be closely monitored by their doctors as they are more likely to have congenital heart disease.

The most common side effects of Norditropin® include: headaches, muscle pain, joint stiffness, high blood sugar (hyperglycemia), sugar in your urine (glucosuria), swollen hands and feet due to fluid retention, and redness and itching in the area you inject. If you have headaches, eye problems, nausea or vomiting (these may be symptoms of raised pressure in the brain), contact your healthcare provider right away.

Norditropin® may affect how other medicines work, and other medicines may affect how Norditropin® works so be sure to tell your healthcare provider about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you take: glucocorticoid medication, thyroid hormone, insulin or other medicine for diabetes, medicines that are metabolized by the liver (e.g., corticosteroids, sex steroids, anticonvulsants, cyclosporine), or oral estrogen replacement medicine.

For more information, please click here for complete Norditropin® Prescribing Information.

Norditropin® is a prescription medication.

Novo Nordisk provides patient assistance for those who qualify. Please call 1-866-310-7549 to learn more about Novo Nordisk assistance programs.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088

Norditropin®, FlexPro® and Norditropin NordiFlex® are registered trademarks of Novo Nordisk Health Care AG. NovoFine® and Novo Nordisk® are registered trademarks and Growth Track Wizard™ is a trademark of Novo Nordisk A/S.
Novo Nordisk Inc., 100 College Road West, Princeton, New Jersey 08540 U.S.A.
© 2011 Novo Nordisk    0411-00002479-1    July 2011